Cyclin D1 mediates pain behaviour in a rat model of breast cancer-induced bone pain by a mechanism involving regulation of the proliferation of spinal microglia

AimsThe involvement of cyclin D1 in the proliferation of microglia, and the generation and maintenance of bone cancer pain (BCP), have not yet been clarified.We investigated the expression of microglia and cyclin D1, and the influences of cyclin D1 on pain threshold.MethodsFemale Sprague Dawley (SD) rats were used to establish a rat model of BCP, a

read more

The osteoporosis care gap in Canada

Abstract Background The presence of a fragility fracture is a major risk factor for osteoporosis, and should be an indicator for osteoporosis diagnosis and therapy.However, Wrapping Paper the extent to which patients who fracture are assessed and treated for osteoporosis is not clear.Methods We performed a review of the literature to identify the p

read more

Research on the Restoration of the Traditional Residence “Wang’s Old House” in the Vicinity of Cizhou Kiln Based on Oral History

The traditional folk houses in Pengcheng Town preserve the architectural style of the southern part of Hebei Province and integrate local living customs and cultural traditions.These folk houses reflect the deep cultural origins of Pengcheng and the Cizhou Kiln.“Wang’s Old House” is the largest and tallest building among numerous residential

read more

PERBANDINGAN KEAKURATAN LABA PERMANEN, LABA AGREGAT, DAN ARUS KAS OPERASI UNTUK MEMPREDIKSI ARUS KAS OPERASI MASA DEPAN

The goal of this research is to compare the accuracy of three prediction models which are permanent earnings, aggregate earnings and operational cash flow in prediction future operational cash flow.The hypotheses which are proposed in this research are H1: permanent earnings are more accurate than aggregate earnings in prediction future operational

read more